The drug was initially explored for psychiatric use due to its structural similarity to serotonin and safety profile. Swiss chemist Albert Hofmann first synthesized LSD in 1938 and discovered its powerful psychedelic effects in 1943 after accidental ingestion. At higher doses, it can induce visual and auditory hallucinations, ego dissolution, and anxiet


This may imply that the hallucinogenic effects are mainly mediated by cortico‐cortical neural circuits rather than by thalamo‐cortical circuits as proposed earlier by some scientists . In a recent study, Gonzalez‐Maeso et al. compared 2‐HT2A agonists with and without hallucinogenic activity in mice. LSD is probably best called a mixed 5‐HT2/5‐HT1 receptor partial agonist.
A potential risk of frequent repeated long-term use of LSD and other serotonergic psychedelics is cardiac fibrosis and valvulopathy due to serotonin 5-HT2B receptor agonism. There is no indication that similar effects occur with other psychedelics like phenethylamines and simple tryptamines, which lack dopamine receptor agonism. LSD is approximately 200 times as potent as psilocybin and 5,000 times as potent as mescaline, meaning that it produces effects of similar magnitude at 1/200 and 1/5,000 times the respective doses. Noticeable effects can occur with doses of LSD as low as 20 μg, which is around 1/200th the mass of a grain of sand. This means that it produces its pharmacological effects at very small doses, with its dose range measured in micrograms (μg); that is, millionths of a gram.
What if I use other drugs with LSD?
This is when an LSD experience reoccurs usually as a visual distortion. Some people who regularly use LSD may eventually experience flashbacks. It is important to understand the difference between a bad trip and an overdose. Provide buylsdonline.io as much information as possible about the drug taken, the amount, timing, any other substances involved, and any pre-existing medical conditions.
How does it make people behave?
LSD, a classical psychedelic, is deemed physiologically safe at standard doses (50–200 μg) and its primary risks lie in psychological effects rather than physiological harm. Taking a large dose of psychedelics is the most common cause of a bad trip, but other factors like age, sex, mental state, and past experiences with the drug can also contribute.12-14 LSD (lysergic acid diethylamide) is a psychedelic drug, which means it can affect all senses, altering a person’s thinking, sense of time and emotion

A recent animal experiment with rats (130 μg/kg LSD i.v. for 5 consecutive days), who were previously trained to discriminate LSD from saline, indicated a decrease in 5‐HT2A receptor signaling caused by a reduction of 5‐HT2A receptor density

This view is limited by the fact that a few 5‐HT receptors are excitatory ion channels (5‐HT3) and some subtypes may have excitatory effects depending upon the G protein coupling within specific neuron


There appears to be no significant acute tolerance to the subjective effects of LSD. Researchers state that the alleged physiological toxicity of LSD is likely due to psychoactive substances other than LSD. Fatalities involved in NBOMe intoxication suggest that a significant number of individuals ingested the substance which they believed was LSD, and researchers report that "users familiar with LSD may have a false sense of security when ingesting NBOMe inadvertently


Still others describe experiences with illegal LSD, obtained for philosophic, artistic, therapeutic, spiritual, or recreational purposes. About the same time as blotter paper LSD came "Windowpane" (AKA "Clearlight"), which contained LSD inside a thin gelatin square a quarter of an inch (6 mm) across. More than 200 buylsdonline.io types of LSD tablets have been encountered since 1969 and more than 350 blotter paper designs have been observed since 197


LSD, via activation of serotonin 5-HT2 receptors, has been found to potentiate MDMA-induced serotonergic neurotoxicity in rodents. Single macrodoses of LSD do not produce such changes in rodents, but the preceding findings may have implications for continuous psychedelic microdosing with LSD. LSD, like other psychedelics, has been found to increase the expression of genes related to synaptic plasticity and hence to have psychoplastogenic effects. The very high potency of LSD in producing psychedelic-like effects is also the case in animals, including rodents and monkey


Dosing of animals (rats and cats) with very high doses of LSD (up to 100 μg/kg i.v.) leads to mild autonomic changes of mydriasis, tachycardia, tachypnea, hyperthermia, hypertonia, and hyperglycemia . The threshold dose for measurable sympathomimetic effects in humans is 0.5–1.0 μg/kg LSD p.o. Lower doses may not capture the real cognitive effects LSD may provoke. Though he synthesized many lysergic acid derivatives, none had LSD's unique spectrum of psychological effects. See 'What are the effects of taking drugs? The effects of taking LSD with other drugs can be unpredictable.
Is it dangerous to mix with other drug