Best Wrinkle Creams Of 2025, Tested By Dermatologists And Beauty Editors
Sure, nothing quite captures the effects of the nerve-freezing, muscle-paralyzing, skin-tightening power of botulinum toxin A (which sounds freakier than it is, we promise), but these formulas come pretty close. These pain-free, comparatively inexpensive products, when used consistently and as directed, can deliver results similar to that of a loving jab in the face from your derm. Sorry if this is already obvious to most, but I’ve only just realised that hydrated skin is the answer! We interviewed two board-certified dermatologists for their product recommendations and best practices for application and use over time. It is best used solo, as it starts to pill when layered with other products.
Dr. Dennis Gross Skincare Retinol + Ferulic Wrinkle Cream
"The best line-fighting creams are those that help build our skin's own building blocks, namely collagen and elastin fibers," explains Deanne Robinson, MD, a firming face moisturizer Connecticut-based board-certified dermatologist. Injectables reign supreme when it comes to getting rid of fine lines, smoothing texture, and plumping lax skin. The fragrance-free formula was designed with sensitive skin in mind (encapsulated retinol minimizes the risk of irritation while still delivering results), making it a gentle yet powerful option for most people looking to target wrinkle


I think as long as your skin is hydrated these anti-wrinkle creams are just a money making ploy! I think I have tried every anti-wrinkle cream going; from Estée Lauder night repair to L’Oréal Revitalift and not one of them improved my fine lines. Bedtime is a great time to tap into the powers of an anti-wrinkle cream; it’s when your skin is in a natural reparative state and can better utilize active ingredients. Saunders takes great pride in heavily researching and testing featured beauty products, such as strengthening shampoos and body washes for dry skin on our site. "Even though many people start using anti-aging products in their forties or fifties when signs of aging have become more prominent, your skin’s natural collagen production actually starts to decline around age 25," she says.
Best Overall: SkinCeuticals P-Tiox
It refers to the dermal-epidermal junction—the meeting point between your skin’s upper and lower layers, and one of the first places to show uneven texture and a loss of firmness as we age. Body Reform Treatment Serum uses a potent 2% granactive retinoid (an advanced retinoid that delivers retinoic acid-level results with far less irritation) to smooth rough texture, firm crepey areas, and improve the look of dark spots. Retinal (a.k.a. retinaldehyde) is one step closer to prescription-strength retinoic acid, "with studies showing that it works ten times faster than retinol," says Dr. Palmer.
Neutrogena Rapid Wrinkle Repair Regenerating Cre


So how do firming face moisturizer you increase your collagen? As we get older, we bid farewell to the collagen stores we enjoyed in our youth. Talk to your provider to create a plan that fits your skin goals and lifestyl

Our tester noted that it does take a couple of minutes to fully absorb, but it doesn’t leave any residue behind, just super moisturized skin (which may make it better as part of a nighttime skincare routine


In some cases, it’s as simple as seeking out collagen-rich foods or supplement your diet with nutrient-rich additives or drinks. In-office chemical peels, high concentrations of exfoliating acids applied for a short period of time then removed, can result in collagen rebuilding within skin’s layers (13). This subtype of collagen isn’t as "complete" as regular collagen since it’s produced in haste. However, the authors of the paper note that more scientific studies are needed before any definitive conclusions about light therapy’s efficacy can be drawn. One research paper found that certain light frequencies (most notably red light) improve skin’s collagen levels (10). The reality is that the best way to improve collagen synthesis is to take a holistic approach that involves skin care, diet, lifestyle and in some cases, supplementation.
Dieux Air Angel Collagen & Peptide Hydrating Gel Cream
Yes the product is tested that heavy metal concentrations are below acceptable regulatory thresholds (lead, arsenic, cadmium, mercury). Is this product tested for heavy metals? Is this product Keto-friendly / Fasting-friendly? This product is not Halal-certified, however it does not contain alcohol, pork or animal derivatives other than fish. Is this product Halal? The product is meant to be taken indefinitely (give or take periodic breaks), so there may be some reversal in benefits if stopped completely.
SkinCeuticals Physical Fusion UV Defense SPF 50
We implemented these collagen creams into our regular skincare routines, layering them with our regular products, from SPF to moisturizers to retinols to everyday makeup. How to take care of the collagen you have and how to boost your skin’s natural collagen production are buzzy topics, and tons of brands claim their key ingredients (vegan collagen, peptides, you name it) can get the job done. Other (industry-funded) studies have suggested that oral products with high amounts of the collagen peptides prolylhydroxyproline firming face moisturizer and hydroxyprolylglycine can improve the moisture and appearance of the ski